Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers
Identifieur interne : 000C70 ( Main/Exploration ); précédent : 000C69; suivant : 000C71Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers
Auteurs : Logan C. Walker [Nouvelle-Zélande] ; Louise Marquart [Australie] ; John F. Pearson [Nouvelle-Zélande] ; George A R. Wiggins [Nouvelle-Zélande] ; Tracy A. O'Mara [Australie] ; Michael T. Parsons [Australie] ; Daniel Barrowdale [Royaume-Uni] ; Lesley Mcguffog [Royaume-Uni] ; Joe Dennis [Royaume-Uni] ; Javier Benitez [Espagne] ; Thomas P. Slavin [États-Unis] ; Paolo Radice [Italie] ; Debra Frost [Royaume-Uni] ; Andrew K. Godwin [États-Unis] ; Alfons Meindl [Allemagne] ; Rita Katharina Schmutzler [Allemagne] ; Claudine Isaacs [États-Unis] ; Beth N. Peshkin [États-Unis] ; Trinidad Caldes [Espagne] ; Frans Bl Hogervorst [Pays-Bas] ; Conxi Lazaro [Espagne] ; Anna Jakubowska [Pologne] ; Marco Montagna [Italie] ; Xiaoqing Chen [Australie] ; Kenneth Offit [États-Unis] ; Peter J. Hulick [États-Unis] ; Irene L. Andrulis [Canada] ; Annika Lindblom [Suède] ; Robert L. Nussbaum [États-Unis] ; Katherine L. Nathanson [États-Unis] ; Georgia Chenevix-Trench [Australie] ; Antonis C. Antoniou [Royaume-Uni] ; Fergus J. Couch [États-Unis] ; Amanda B. Spurdle [Australie]Source :
- European Journal of Human Genetics [ 1018-4813 ] ; 2017.
Abstract
Genome-wide studies of patients carrying pathogenic variants (mutations) in
Url:
DOI: 10.1038/ejhg.2016.203
PubMed: 28145423
PubMed Central: 5386423
Affiliations:
- Allemagne, Australie, Canada, Espagne, Italie, Nouvelle-Zélande, Pays-Bas, Pologne, Royaume-Uni, Suède, États-Unis
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- to stream Ncbi, to step Curation: 004249
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for <italic>BRCA1</italic>
pathogenic variant carriers</title>
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</author>
<author><name sortKey="O Mara, Tracy A" sort="O Mara, Tracy A" uniqKey="O Mara T" first="Tracy A" last="O'Mara">Tracy A. O'Mara</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Parsons, Michael T" sort="Parsons, Michael T" uniqKey="Parsons M" first="Michael T" last="Parsons">Michael T. Parsons</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Human Genetics Group, Spanish National Cancer Centre (CNIO)</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Slavin, Thomas P" sort="Slavin, Thomas P" uniqKey="Slavin T" first="Thomas P" last="Slavin">Thomas P. Slavin</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Population Sciences Division of Clinical Cancer Genomics, City of Hope Clinical Cancer Genomics Community Research Network</institution>
, Duarte, CA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT)</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center</institution>
, Kansas City, KS,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich</institution>
, Munich,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita Katharina" sort="Schmutzler, Rita Katharina" uniqKey="Schmutzler R" first="Rita Katharina" last="Schmutzler">Rita Katharina Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne</institution>
,<country>Cologne, Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago</wicri:regionArea>
<wicri:noRegion>MC 2115 Chicago</wicri:noRegion>
<wicri:noRegion>MC 2115 Chicago</wicri:noRegion>
<wicri:noRegion>MC 2115 Chicago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Lombardi Comprehensive Cancer Center, Georgetown University</institution>
, Washington, DC,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peshkin, Beth N" sort="Peshkin, Beth N" uniqKey="Peshkin B" first="Beth N" last="Peshkin">Beth N. Peshkin</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Lombardi Comprehensive Cancer Center, Georgetown University</institution>
, Washington, DC,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Molecular Oncology Laboratory CIBERONC, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hogervorst, Frans Bl" sort="Hogervorst, Frans Bl" uniqKey="Hogervorst F" first="Frans Bl" last="Hogervorst">Frans Bl Hogervorst</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Family Cancer Clinic, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name>
<affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet</institution>
, Barcelona,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS</institution>
, Padua,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Medicine, Cancer Biology and Genetics, Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center</institution>
, New York, NY,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J" last="Hulick">Peter J. Hulick</name>
<affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Center for Medical Genetics, NorthShore University HealthSystem</institution>
, Evanston, IL,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital</institution>
, Toronto, Ontario,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Department of Clinical Genetics, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L" last="Nussbaum">Robert L. Nussbaum</name>
<affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Department of Medicine and Institute for Human Genetics, University of California</institution>
, San Francisco, CA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Medicine and the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>
, Philadelphia, PA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name>
<affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B" last="Spurdle">Amanda B. Spurdle</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, Queensland,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">European Journal of Human Genetics</title>
<idno type="ISSN">1018-4813</idno>
<idno type="eISSN">1476-5438</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Genome-wide studies of patients carrying pathogenic variants (mutations) in <italic>BRCA1</italic>
or <italic>BRCA2</italic>
have reported strong associations between single-nucleotide polymorphisms (SNPs) and cancer risk. To conduct the first genome-wide association analysis of copy-number variants (CNVs) with breast or ovarian cancer risk in a cohort of 2500 <italic>BRCA1</italic>
pathogenic variant carriers, CNV discovery was performed using multiple calling algorithms and Illumina 610k SNP array data from a previously published genome-wide association study. Our analysis, which focused on functionally disruptive genomic deletions overlapping gene regions, identified a number of loci associated with risk of breast or ovarian cancer for <italic>BRCA1</italic>
pathogenic variant carriers. Despite only including putative deletions called by at least two or more algorithms, detection of selected CNVs by ancillary molecular technologies only confirmed 40% of predicted common (>1% allele frequency) variants. These include four loci that were associated (unadjusted <italic>P</italic>
<0.05) with breast cancer (<italic>GTF2H2</italic>
, <italic>ZNF385B</italic>
, <italic>NAALADL2</italic>
and <italic>PSG5</italic>
), and two loci associated with ovarian cancer (<italic>CYP2A7</italic>
and <italic>OR2A1</italic>
). An interesting finding from this study was an association of a validated CNV deletion at the <italic>CYP2A7</italic>
locus (19q13.2) with decreased ovarian cancer risk (relative risk=0.50, <italic>P</italic>
=0.007). Genomic analysis found this deletion coincides with a region displaying strong regulatory potential in ovarian tissue, but not in breast epithelial cells. This study highlighted the need to verify CNVs <italic>in vitro</italic>
, but also provides evidence that experimentally validated CNVs (with plausible biological consequences) can modify risk of breast or ovarian cancer in <italic>BRCA1</italic>
pathogenic variant carriers.</p>
</div>
</front>
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<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>Italie</li>
<li>Nouvelle-Zélande</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Walker, Logan C" sort="Walker, Logan C" uniqKey="Walker L" first="Logan C" last="Walker">Logan C. Walker</name>
</noRegion>
<name sortKey="Pearson, John F" sort="Pearson, John F" uniqKey="Pearson J" first="John F" last="Pearson">John F. Pearson</name>
<name sortKey="Wiggins, George A R" sort="Wiggins, George A R" uniqKey="Wiggins G" first="George A R" last="Wiggins">George A R. Wiggins</name>
</country>
<country name="Australie"><noRegion><name sortKey="Marquart, Louise" sort="Marquart, Louise" uniqKey="Marquart L" first="Louise" last="Marquart">Louise Marquart</name>
</noRegion>
<name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<name sortKey="O Mara, Tracy A" sort="O Mara, Tracy A" uniqKey="O Mara T" first="Tracy A" last="O'Mara">Tracy A. O'Mara</name>
<name sortKey="Parsons, Michael T" sort="Parsons, Michael T" uniqKey="Parsons M" first="Michael T" last="Parsons">Michael T. Parsons</name>
<name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B" last="Spurdle">Amanda B. Spurdle</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name>
</noRegion>
<name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name>
<name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
<name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
</noRegion>
<name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Slavin, Thomas P" sort="Slavin, Thomas P" uniqKey="Slavin T" first="Thomas P" last="Slavin">Thomas P. Slavin</name>
</noRegion>
<name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name>
<name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name>
<name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J" last="Hulick">Peter J. Hulick</name>
<name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name>
<name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L" last="Nussbaum">Robert L. Nussbaum</name>
<name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<name sortKey="Peshkin, Beth N" sort="Peshkin, Beth N" uniqKey="Peshkin B" first="Beth N" last="Peshkin">Beth N. Peshkin</name>
</country>
<country name="Italie"><noRegion><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
</noRegion>
<name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
</noRegion>
<name sortKey="Schmutzler, Rita Katharina" sort="Schmutzler, Rita Katharina" uniqKey="Schmutzler R" first="Rita Katharina" last="Schmutzler">Rita Katharina Schmutzler</name>
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<country name="Pays-Bas"><noRegion><name sortKey="Hogervorst, Frans Bl" sort="Hogervorst, Frans Bl" uniqKey="Hogervorst F" first="Frans Bl" last="Hogervorst">Frans Bl Hogervorst</name>
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</country>
<country name="Pologne"><noRegion><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
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<country name="Canada"><noRegion><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name>
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<country name="Suède"><noRegion><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
</noRegion>
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</tree>
</affiliations>
</record>
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